Description
Recombinant full-length human PLCB1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_015192.
1-phosphatidylinositol 4, 5-bisphosphate phosphodiester-ase beta-1 (PLCB1) is one of the best characterized isoenzymes in the inositide specific phospholipase C (PI-PLC) family. Responsible for the hydrolysis of the phosphatidilinool-4, 5-bisphophate (PIP2), generating the second messengers inositol-1, 4, 5-triphosphate and di-acylglycerol. It is a key molecule for nuclear inositide signaling, where it plays a role in cell cycle progression, proliferation and differentiation